Fat and metabolic research peptides
Fragments and mitochondrial-derived peptides studied in adipose and metabolic models.
Fragments and mitochondria-derived peptides studied in adipose and metabolic models. This is a small category held together by the kind of model its literature uses rather than by a shared target, and the entries in it have little pharmacology in common.
Two things are worth carrying into them. The first is that a fragment is not a miniature of the protein it came from: activity belongs to a specific structural arrangement, and removing part of a sequence can remove the property the parent was named for. Several entries in this part of the library turn on that point. The second is that these compounds are characterised to very different depths, from a defined molecular target to a published mechanism that is a list of downstream observations.
The receptor-agonist compounds most often discussed alongside these are in GLP-1 and metabolic receptor agonists, which is a separate category because its members are grouped by receptor rather than by model.
Compounds listed below without a link do not yet have a published entry.
Compounds in this category
3 of 3 entries are published. Compounds without a published entry are listed without a link.
- AOD-9604AOD-9604 is a synthetic sixteen-residue peptide corresponding to the C-terminal fragment of human growth hormone with an added N-terminal tyrosine. Its published evidence base is preclinical and analytical: no completed human trial of the compound is indexed in the peer-reviewed literature, and it is not approved by the FDA for any use.
- AdipotideAdipotide is an investigational chimeric peptidomimetic that joins a vascular homing peptide to a proapoptotic sequence built from D-amino acids. Its published evidence is preclinical; the single registered human trial was terminated after four participants and has never reported. It is not approved by the FDA for any use.
- MOTS-cMOTS-c is a sixteen-residue peptide encoded by a short open reading frame inside the mitochondrial 12S ribosomal RNA gene — an endogenous mitochondrial-derived peptide rather than a designed analogue. Its published evidence base is largely preclinical and observational, and it is not approved by the FDA for any use.
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