Longevity and senescence research peptides

Peptides studied in telomere, senescence and cell-cycle models.

Peptides studied in telomere, senescence and cell-cycle models. The category is defined by the model system its literature uses, which is a deliberately narrow definition and a necessary one, because the claims made for compounds in this area in general circulation are far broader than the published record behind them.

Two cautions apply across every entry here. The first is that the endpoints in this literature are cellular and molecular — telomerase activity, senescence markers, cell-cycle protein expression — and an endpoint of that kind is a long way from an outcome in an organism. The second is that much of the work is in cell culture or in short-lived model organisms, neither of which establishes anything about humans.

Several members of this category are also peptide bioregulators, and the entries note where a compound belongs to both.

Compounds listed below without a link do not yet have a published entry.

Compounds in this category

3 of 3 entries are published. Compounds without a published entry are listed without a link.

  • EpitalonEpitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, designed from the amino acid composition of a bovine pineal gland extract and studied chiefly by one research group in St Petersburg. It is not approved by the FDA for any indication.
  • N-Acetyl EpitalonN-Acetyl Epitalon is an acetylated analogue of the synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly). It is recorded in PubChem as a distinct chemical substance and has no indexed research literature of its own. It is not approved by the FDA for any indication.
  • FOXO4-DRIFOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the interaction between the transcription factor FOXO4 and p53, causing senescent cells to undergo apoptosis. Its entire research record is cell culture and rodent work. It is not approved by the FDA for any indication.

For in vitro research use only. This material is a laboratory reagent. It is not a drug, food, dietary supplement, or cosmetic and is not for human or veterinary use, including ingestion, injection, or any other administration. No information on this page describes or implies any effect in humans or animals. Sold only to researchers under our Terms of Sale.